Background: Green tea intake is accompanied with a lower incidence of cardiovascular\ndisease, cancer and neurodegenerative disorders; hence green tea\nextract has been included as dietary supplement along with other supplements\nand multivitamins. Aim of the Work: Studying the effect of cyclophosphamide\nadministration on the liver of adult male albino rats and the possible\nprotective role of green tea extract. Material and Methods: The current study\nwas carried out on 45 adult male albino rats. They were divided into three\nequal groups (each included 15 rats). Group I (control group) was injected\nintraperitoneally with normal saline at a dosage of 0.5 mg/kg body weight\ntwice weekly for 9 weeks. Group II was injected intraperitoneally with cyclophosphamide\n(CP) (150 mg/kg/day) for two weeks. Group III: rats received\ngreen tea extracts orally (50 mg/kg/day) for three weeks, and then continued\nfor further two weeks concomitantly with intraperitoneally cyclophosphamide\n(CP) injected (150 mg/kg/day). Results: Rats exposed to cyclophosphamide\n(CP) showed several histological and histochemical changes in their liver.\nThese changes were improved by using green tea. Conclusion: The present\nwork showed that green tea had preventive and therapeutic effect upon livers\nof albino rats after they were exposed to CP.
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